Beilstein J. Org. Chem.2013,9, 223–233, doi:10.3762/bjoc.9.26
adhesive surfaces.
Keywords: azobenzene glycosides; bacterial adhesion; E/Z photoisomerisation; FimH antagonists; mannobiosides; molecular switches; sweetswitches; Introduction
Adhesion of bacteria to surfaces can be a severe problem both in vivo and in vitro. Hence, inhibition of bacterial adhesion by
introduced lately and shown to be of medical relevance as FimH antagonists [6]. Thus, our novel “sweetswitches” [15] appear to be highly promising FimH ligands, with the additional feature of a photoswitchable moiety. The biomedicinal potential of azobenzene glycosides seems even higher when their
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Graphical Abstract
Figure 1:
The α-(1→3)-linked mannobioside α-D-Man-(1→3)-D-Man 1 (B) is a potent disaccharide ligand for the b...